牛磺酸对沙鼠脑缺血—再灌注损伤的脑保护作用实验研究

A Study of Protective Effect of Taurine on Brain Cells with Ischemic Reperfusion Damage in Rats.

目的 为了探讨牛磺酸对脑缺血再灌注损伤的作用。 方法 建立沙土鼠脑缺血再灌注模型进行实验。设立实验组G3( 注射牛磺酸组) 、实验组G2( 不用任何药物组) 及对照组G1 。处死动物后,即时分别检测各组血浆内皮素、脑组织脂质过氧化物、脑组织湿/ 干重比值、脑组织学光镜检查等。 结果 四项检测方法从不同方面证实牛磺酸对脑缺血再灌注损伤有抗自由基,稳定细胞膜,降低内皮素,保护脑组织细胞等抗脑缺血再灌注损伤的脑保护作用,与未用牛磺酸组有显著差别。

Objective To study the effect of taurine on rats with cerebral ischemic reperfusion damage. Methods Taurine group(G 3)、non medication group(G 2) and control group(G 1) were established respectively. The endothelin (ET)、 Lipo superoxide in the brain tissue and the ratio of wet dry brain tissue in weight were measured in each group,and cerebral histological optical microscope was applied correspondingly. Results Taurine had the effect of anti free radical on cerebral ischemic reperfusion damage, decreasing ET and protecting brain cellfunction. There was abvious difference in comparing with non meclication group. Conclusions Our study of taurine could supply laboratory evidence for treating cerebral ischemic disease.