莽吉柿中几种双苯吡酮和蒽醌类成分的分离与鉴定

Isolation and Identification of Several Xanthones and Anthraquinone from Pericarpium Garciniae Mangostanae

对莽吉柿(Pericarpium Garciniae Mangostanae)85%乙醇提取物进一步分离,得到8个双苯吡酮类化合物和1个蒽酮类化合物,经理化性质和NMR及MS谱学数据鉴定分别为α-倒捻子素-3,6-二乙酸酯(α-mangostin-3,6-diyl diacetate,Ⅰ)、1,5,8-三羟基-3-甲氧基-2,4-双-(3-甲基丁-2-烯)双苯吡酮(8-hydroxycud-raxanthone G,Ⅱ)、1,3-二羟基-6,7-二甲氧基-2,8-双-(3-甲基丁-2-烯基)双苯吡酮(Cowaxanthone B,Ⅲ)、1,6-二羟基-3,5-二甲氧基-2-(3-甲基丁-2-烯基)双苯吡酮(Cowaxanthone A,Ⅳ)、1,5-二羟基-4-(3-甲基丁-2-烯基)-6′,6′-二甲基吡喃[2′,3′:3,2]双苯吡酮(trapezifolixanthone,Ⅴ)、1,6-二羟基-6′,6′-二甲基吡喃[2′,3′:7,8]-6″,6″-二甲基吡喃[2″,3″:3,2]双苯吡酮(brasilixanthone B,Ⅵ)、1,3,5-三羟基-2-(3-甲基丁-2-烯)-4-(1,1-二甲基-2-烯丙基)双苯吡酮(Allanxanthone A,Ⅶ)、1,3,8-三羟基-5-甲氧基-2,4-双-(3-甲基丁-2-烯)双苯吡酮(2,4-di-(3-methylbut-2-enyl)-1,3,8-trihydroxy-5-methoxyxanthone,Ⅷ)、1,4,8-三羟基-6-甲基-3-甲氧基-9,10-蒽酮(1,4,8-trihydroxy-6-methyl-3-methoxy-9,10-anthraquinone,Ⅸ)。其中化合物Ⅰ、Ⅴ、Ⅵ、Ⅶ、Ⅸ为首次从藤黄属植物中分离得到,化合物Ⅱ、Ⅲ、Ⅳ、Ⅷ为首次从该植物中分离得到。

Eight xanthones and one anthraquinone were isolated by chromatographic separation of 85% ethanol extract of Pericarpium Garciniae Mangostanae.The obtained compounds were identified as α-mangostin-3,6-diyl diacetate（Ⅰ）,8-hydroxycudraxanthone G（Ⅱ）,cowaxanthone B（Ⅲ）,cowaxanthone A（Ⅳ）,trapezifolixanthone（Ⅴ）,brasilixanthone B（Ⅵ）,allanxanthone A（Ⅶ）,2,4-di-（3-methylbut-2-enyl）-1,3,8-trihydroxy-5-methoxyxanthone（Ⅷ）,and 1,4,8-trihydroxy-6-methyl-3-methoxy-9,10-anthraquinone（Ⅸ） by physico-chemical properties,NMR and MS spectral data,compounds Ⅰ,Ⅴ,Ⅵ,Ⅶ and Ⅸ were isolated from plants of Garcinia for the first time,and compounds Ⅱ,Ⅲ,Ⅳ and Ⅷ were isolated from Pericarpium Garciniae Mangostanae for the first time.