摘要
目的：研究Ⅳ型胶原与子宫颈癌浸润及转移的关系。方法：采用免疫组化方法对６５例宫颈浸润癌进行Ⅳ型胶原的表达。结果：Ⅱｂ－Ⅲａ期子宫颈癌基底膜断裂或缺损明显多于Ⅰ－Ⅱａ期，早期子宫颈浸润癌发生淋巴结转移组其基底膜断裂或缺损程度明显高于未转移组。
Objective: To study the relation of type - Ⅳcollagen with the invasion and metastasis of cervieal cancer. Methods: With immunohistochemical staining methods, the basement membrane expressed by type -Ⅳ collagen was evaluated in 65 patients with cervical cancer. Result: Pattem Ⅲ (fragmented or absent basement membrane) was more frequently observed in advanced cervical cancer (stage Ⅱ a - Ⅲa) than in patients with early cervital cancer (stage Ⅰ a - Ⅱa).This pattern (early cervical cancer) was associated with the presence of lymph nede metastasis. Conclusion: The study shows that in patients with early stage cervical cancer the basement membrane pattemrn expressed as type - Ⅳ collagen staining pattern may be a useful mark in predicating lymph node metastasis and prognosis.
