维生素C和地塞米松增加兔血红细胞渗透抵抗性

Vitamine C and Dexamethasone Improve Osmotic Resistibility of Rabbit's Erythrocyte

目的研究尿素、乌拉坦、维生素 Ｃ、地塞米松对兔血红细胞渗透抵抗性的影响，为临床用药提供一定的理论依据。方法实验分对照组、维生素Ｃ组、尿素组、维生素Ｃ＋尿素组、维生素Ｃ＋乌拉坦组、尿素＋乌拉坦＋维生素Ｃ组、尿素＋乌拉坦＋地塞米松组。观察维生素Ｃ、尿素及二者同时作用，维生素Ｃ、乌拉坦及二者同时作用对红细胞渗透脆性的影响以及地塞米松和维生素Ｃ抑制尿素和乌拉坦所致的红细胞渗透脆性增加的影响。结果维生素Ｃ组与对照组红细胞渗透脆性有显著差异（Ｐ< ０．０１），尿素＋乌拉坦组与尿素＋乌拉坦＋维生素Ｃ组红细胞渗透脆性有显著差异（Ｐ<０．０１），尿素＋乌拉坦组与尿素＋乌拉坦＋地塞米松组红细胞渗透脆性有显著差异（Ｐ<０．０１）。结论维生素Ｃ单独作用增加红细胞渗透抵抗性，维生素Ｃ和地塞米松具有抑制尿素和乌拉坦所致红细胞渗透脆性增加的作用。

Objective To study the effect of urea,ethyl carbamate, vitamine c and dexamethasone on rabbit's erythrocyte osmotic fragility and provide the theoretical basis for clinical medicine. Methods The test was divided into control group, vitamine c group, urea group,vitamine c and urea group, vitamine c and ethyl carbamate group,urea and ethyl carbamate group,urea、ethyl carbamate and vitamine c group,urea、ethyl carbamate and dexamethasone group. Their effects on rabbit's erythrocyte osmotic fragility were observed. Results Vitamine c group versus control group (P<0.01),urea and ethyl carbamate group versus urea、ethyl carbamate and dexamethasone group urea and carbamate versus urea、ethyl carbamate and vitamine c group (P<0.01) their erythrocyte osmotic fragility has significant difference respectively. Conclusion Vitamine c increased significantly erythrocyte osmotic resistibility. Vitamine c and dexamethasone had significantly inhibitory effect on increase of erythrocyte osmotic fragility induced by urea and ethyl carbamate.