用即凝血栓制备家兔肺栓塞模型探讨

Discussion of the preparation of pulmonary embolism model with thromboembolus in rabbits

目的用即凝血栓制备家兔肺血栓栓塞模型。方法栓塞组自颈静脉注入自体小血凝块建立家兔急性肺栓塞模型,对照组注入生理盐水。结果栓塞组肺可出现点、片状出血,肺动脉内可见血栓。结论 (1)用即凝自体血栓制备家兔肺栓塞模型方便、简易、实用性强。(2)肺内血栓机化最多从栓塞后5天开始。

Objective To explore the way of preparing thromboembolus by exploiting self blood clots during short period. Methods Models of PE were set up by injeetion of auto - blood clots into femoral vein in PE group while in control group by injection of sterile saline water. Results Peteehial and patchy hemorrhehages were observed on the surfaces of embolic lungs. The injected blood clots eould be found by microscope. Conclusion （ 1 ） It is pratieal and simple to prepare thromboembolus by exploiting self blood elots during short period; （2） The thrombus organization in this model of PTE appears at the fifth day.