脑血管病患者恢复期血脂水平的研究

Study on Blood Fat Level in Patients with Ischemia Cerebrovascular Diseases in Restoration Satge

为探讨血高密度脂蛋白胆固醇（HDL－C）、载脂蛋白（aPo）及脂蛋白（a）[LP（a）]在脑血管病（CVD）发病机理中的作用，对68例CVD患者和48例非脑血管病患者（对照组）外周血HDL－C、aPoA1、aPoB100及LP（a）的含量进行检测并做了对比研究。结果：发现LP（a）比HDL－C、aPoA1及aPoB100对CVD的判别更敏感。而且缺血性脑血管病（ICVD）的HDL－C、aPoA1及aPoA1／B100均比对照组呈显著降低（P＜0．05～001），LP（a）较对照组呈显著性增高（P＜0．01）；但脑出血（CH）的aPoA，及LP（a）均较对照组呈显著性降低（P＜0．001）。提示低水平的HDL－C或aPoA1／B100降低可能是发生ICVD的危险因素之一；高水平的LP（a）是缺血性脑卒中的独立危险因素。CH与ICVD的检测结果恰好相反。我们认为aPoA1／B100比值及LP（a）水平可作为预测CVD的二项很有用的指标。而后者似乎是判别缺血性还是出血性脑卒中最有意义的因素。

In order to investigate the pathogenetic role of HDL-C. apolipoproteins (aPo) and lipoprotein (a) [LP(a)] in the cerebrovascular disease (CVD). the blood levels of HDL-C, aPoA1, aPoB100 and LP (a) were determined in 68 patients with CVD and 48 patients without CVD as control group and compared. The results showed that LP(a) in diagnosing CVD was more sensitive than HDL-C. aPoA1, aPoB100, The blood levels of HDL-C, aPoA1l,aPoB100 and the ratio of aPoA1 /aPoB100 in ischemia CVD were obviously decreased as compared with those in control group (P<0. 05 to 0. 01 ). while LP (a) was significantly increased (P<0. 001 ). The levels of aPo A1 and LP (a) in cerebral hemorrhage were markedly higher than in control group (P<0. 01 ). It was suggested that lower level of HDL-C or decreased aPo A1/B100 ratio may be one of the risk factors for ischemia CVD. High level of LP (a) was theindependent risk factor for ischemia stroke. aPo A1/B100 ratio and LP (a) level might be used as useful indicators for the prognosis of CVD.