摘要
目的：建立HPLC测定氟伐他汀钠分散片中氟伐他汀钠含量的方法.方法：色谱柱：THERMO C18（4.6 mm×250 mm,5μm）,检测波长：305 nm,流量：1.2 mL.min-1,进样量：20μL,流动相：0.01 mol.L-1磷酸氢二钠（pH=3.0）-乙腈为40∶60.结果：氟伐他汀钠在0~100μg.mL-1范围内呈现良好的线性关系,Y=3.453 11×104X-5 107.918 4（（R=0.999 9）,含量测定的RSD（相对标准偏差）为1.008%.平均回收率100.34%,RSD=0.41%.结论：本方法简单,快速、准确、重现性好,可以用作氟伐他汀钠分散片的含量测定.
Objective：To establish HPLC method for determining the content of fluvastatin sodium dispersible tablets.Method：Thermo C18 column was used and the mobile phase was 0.01mol·L-1 disodium hydrogen phosphate and acetonitrile（40∶60）,flow rate was 1.2mL·min-1,wavelength was UV at 305nm and the sample volume was 20μL.Results：The fluvastatin sodium concentration had good liner relationship from 0～100μg·mL-1,Y=3.45311×104X-5107.9184（R=0.9999）.The relative standard deviation of the determination is 1.008%.The average recovery was 100.34%,RSD=0.41%.Conclusion：The method was simple,fast,accurate,and precise,could be use to determine the content of fluvastatin sodium dispersible tablets.
出处
《吉林化工学院学报》
CAS
2011年第1期23-25,共3页
Journal of Jilin Institute of Chemical Technology
关键词
氟伐他汀钠
HPLC
含量测定
fluvastatin sodium
HPLC
determination of content
