骨痹丸抗氟作用的研究

Effect of Gupiw an to Fluorosis

目的 了解中药骨痹丸的抗氟作用。方法 采用随机分组实验方法，观察各实验组动物的血、尿、粪、器官组织的氟含量及血、尿 Ｈ Ｏ Ｐ的含量。结果 Ａ 组动物血、尿、粪的氟含量显著增加（ Ｐ ＜ ０．０５）；骨氟含量显著少于 Ｂ 组（ Ｐ ＜ ０．０５）； Ａ 组尿 Ｈ Ｏ Ｐ 显著低于 Ｂ 组（ Ｐ ＜ ０．０１），而与 Ｃ 组无显著差异。结论 骨痹丸通过增加氟的排泄，可减轻氟对骨组织的损害，维持骨的基础结构胶原代谢的稳定。

Objective To understand the effect of Gupiw an to fluorosis. M ethods By ran dom ized controlled trial,the change of fluorine level in blood,urine,dung and other organ of suf fered from skeletal fluorosis experim ental sheep w as observed. The change of H O P level w as ob served in blood and urine. Results The fluorine levelof group A w as higher significantly in blood,urine and dung,low er significantly in skeletal,the H O P level w as low er than that of group B. Con┐clusions Gupiw an m ay lighten skeletal fluorosis,correcting m etabolic disorder of collagen.[