摘要
为观察 Tenascin( T N)在乳腺不典型增生癌变过程中的表达变化,采用 S P免疫组化染色法检测了 50 例不同乳腺组织中 T N 的表达情况。结果显示: 正常及Ⅰ级增生的乳腺组织中无 T N 表达,2 例Ⅱ级不典型增生的乳腺组织中有 T N 表达,Ⅲ级不典型增生及浸润性导管癌中 T N 表达阳性率分别为 80% 和 90% ,与Ⅱ级不典型增生相比明显增高( P< 0.01)。部分癌细胞胞浆中也有 T N 表达。本实验结果提示,重度不典型增生的乳腺组织间质中 T N 的表达可能起限制不典型增生细胞向外生长的作用。
To investigate the changes of tenascin (TN) expression during the course of canceration through atypical hyperplasia of breast epithelia. The SP immunohistochemical method was used to study TN expresson in 50 different breast tissues. Results: There was no TN expression in normal breast and grade Ⅰ hyperplasia; immunostaining of TN was detected in 2 cases with grade Ⅱ atypical hyperplasia; the expression of TN in grade Ⅲ atypical hyperplasia (80%) and infiltrating ductal breast cancer (90%) was significantly higher than that in grade Ⅱ atypical hyperplasia (20%); and immunostaining of TN was detected in part of the cancer cells. Conclusion: These results suggest that TN expression in the stroma of serious atypical hyperplasia may play a role in limiting the outgrowth of hyperplastic epithelia.
出处
《中国普外基础与临床杂志》
CAS
1999年第5期261-262,共2页
Chinese Journal of Bases and Clinics In General Surgery