2型糖尿病患者外周血基质细胞衍生因子1水平与大血管病变的关系

Association of serum level of stromal cell-derived factor-1 with macrovascular complications of type 2 diabetes mellitus

目的探讨2型糖尿病(T2DM)患者外周血基质细胞衍生因子1(SDF-1)水平与大血管并发症的关系。方法测定55例无微血管并发症的T2DM患者和26名健康对照者外周血中SDF-1水平、内皮祖细胞(EPCs)数量、EPCs表面SDF-1的受体CXCR4表达率。糖尿病患者分单纯糖尿病组、大血管病变组。结果 SDF-1水平和EPCs数量对照组、单纯糖尿病组、大血管病变组依次降低(P<0.05或0.01);单纯糖尿病组、对照组、大血管病变组CXCR4表达率依次降低(P<0.05或0.01);SDF-1水平与EPCs数量成正相关(r=0.327,P<0.05),颈动脉内膜中层厚度与SDF-1、EPCs负相关(r=-0.342、-0.298,P<0.05)。结论 T2DM患者外周血中SDF-1/CXCR4轴的变化与大血管并发症的发生、发展有关。

Objective To study the association of serum level of stromal cell-derived factor-1（SDF- 1 ） and its receptor CXCR4 of endothelial progenitor cells （EPCs）from peripheral blood with macrovascular complication of type 2 diabetes mellitus（T2DM）. Methods The study subjects included simple diabetics （n=25）, macrovascular complication group （n）=30） and healthy control （n=26）. The level of serum SDF-1, the positive rate of CXCR4 on EPCs and the number of EPCs were determined. Results SDF-1 level and EPCs number were decreased one by one from control group to simple diabetic group and to the macrovascular complications group （P 〈 0. 05 or 0. 01 ）. CXCR4 expression rate were significantly decreased one by one from the simple diabetic group to the control group and to the macrovascular complications group （P〈0.05 or 0.01）. SDF-1 level was positively correlated with EPCs number. （r= 0. 327,P〈0.05）, carotid intima-media thickness were negatively correlated with SDF-1 and EPCs （r=-0. 342,-0. 298, P〈0.05） in T2DM. Conclusion SDF-1/CXCR4 may be related to macrovascular complications in patients with T2DM.