摘要
目的:研究大黄酚微囊的制备工艺。方法:以包封率为指标,用正交设计法对大黄酚的制备工艺进行研究,对制备的微囊进行体外释药、形态、稳定性研究。结果:用复凝聚法制备的大黄酚微囊,其囊心囊材比、搅拌速度及成囊温度均有显著性差异,当囊心囊材比为1∶4,搅拌速度为200 r.min-1,成囊温度为60℃时,包封率最高,囊径最小。结论:该法制备工艺简单、可靠,产品稳定性好,具有一定的缓释效果。
Objective：To study the preparation technique of chrysophanol mierocapsules. Method： The preparation technique of chrysophanol microcapsules was optimized by orthogonal design; in vitro release of ehrysophanol microcapsules, morphology and its stability were studied. Result： With the complex agglutination method, the encapsulation rate was significantly related to the ratio of coating material, the encapsulation temperature and the stirring speed. The highest rate of production and minimum diameter of mierocapsule were obtained when the ratio of coating material to chrysophanol was 1 ： 4, the temperature of encapsulation was at 60 ~C and the stirring speed was 200 r·min^-1. Conclusion： The process was simple and reliable. The ehrysophanol microeapsules were very stable and could be used as sustained-release preparation.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第3期7-10,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
河北省卫生厅医学科学研究重点课题指导项目(08348)
关键词
大黄酚
微囊
正交设计
制备工艺
体外释放
chrysophanol
microcapsule
orthogonal design
preparation technique
in vitro release
