四磨汤滴丸成型工艺研究

Study on Formulation Technology of Simotang Dropping Pills

目的:研究四磨汤滴丸最佳成型工艺。方法:采用单因素及正交试验进行优选,以丸重变异、崩解时限、外观质量等为指标,考察滴制温度、滴速、滴头口径等因素的影响,优化成型工艺条件。结果:最佳成型工艺为滴制温度75℃,滴速30～40滴/min,滴头口径2.0 mm/5.0 mm。结论:成型工艺稳定可行,适宜工业化生产。

Objective：To establish the optimized preparation of Simotang dropping pills. Method： The optimum extraction process was selected with Single-factor test and orthogonal, taking difference of pill mass, dissolution and the shape of pill as indicators, and through examing the dropping temperature, dropping speed and external diameter of burette to select the best dropp!ng conditions. Result： The best dropping conditions was that the dropping temperature was at 75 ℃, dropping speed was 30 to 40 drops per minutes, internal and external diameter of burette are 2.0 mm and 5.0 mm. Conclusion： The formulation technology is suitable for industrial production.