黄金胶囊对2型糖尿病大鼠胰岛素抵抗的影响

Effects of Huangjin Capsule on Insulin Resistance in Type 2 Diabetic Rats

目的:探讨黄金胶囊对2型糖尿病(T2DM)大鼠胰岛素抵抗(IR)的影响,并初步探讨其作用机制。方法:采用给大鼠腹腔一次性注射小剂量链脲佐菌素(STZ),并加饲高热量饮食(富含脂肪和蔗糖),制备T2DM伴IR大鼠模型,观察黄金胶囊对糖尿病大鼠体重、血糖、血清总胆固醇(TC),甘油三酯(TG),高密度脂蛋白-胆固醇(HDL-C),血清胰岛素和胰岛素敏感性指数的影响。结果:黄金胶囊能降低T2DM伴IR模型大鼠空腹血糖具体剂量;黄金胶囊能降低病鼠血清TC,TG的水平,并提高HDL-C的水平,黄金胶囊能降低病鼠高胰岛素血症,提高了胰岛素敏感性指数;实验中未发现明显的不良反应。结论:黄金胶囊对T2DM伴IR大鼠有降血糖,调节脂代谢紊乱及改善其IR的作用。

Objective：To investigate the effects of Huangjin capsule on insulin resistance in type 2 diabetic rats and the primary pharmacological mechanism. Method： The model of type 2 diabetic-insulin-resistant rats （T2DIRR） was made through intraperitonea injection of lower dosage of streptozocin（30 mg.kg ^- ） and high caloric diet （abounded with sugar ＆ fat）, the effects of Huangjin capsule on weight, blood and serum contents of glucose, TC,TG,HDL-C, observed in the model rats. Result：Huang jin capsule lowered significantly fasting blood glucose （FBG） and improved HDL-C; and reduced the TC, TG in T2DM, IR, and reduced the concentration of insulin in hyperinsulinemia, and potentiated ISI （P 〈 0.01 ） in T2DM, IR. Conclusion：In the experiment with type 2 diabeticinsulin-resistant rats,huang jiM capsule can lower fasting blood glucose （FBG） and reduce level of TC,TG, and improve HDL-C,insulin sensitivity.