中药配方颗粒研究进展(Ⅰ)——文献综合分析

Progress in Chinese Medicinal Dispensing Granule (Ⅰ) ——Comprehensive Analysis of Literature

目的:通过系统分析万方数据、维普资讯和中国知网(CNKI)2001～2010年所收录的中药配方颗粒相关文献的研究内容、研究方法和研究结果,探讨中药配方颗粒的研究现况。方法:检索上述三大中文全文数据库,分类统计中药配方颗粒制剂工艺、化学分析(有效成分鉴别鉴定、质量控制等)、药效学、毒理学、临床应用与临床安全性评价、报道、综述及其他等九类研究文献的年度数量。结果:中药配方颗粒研究文献的数量先增加后减少,其中2007年论文最多;研究内容以化学分析最多,其次是临床应用和报道类,再次是工艺和药效学研究,研究最少的是毒性和临床安全性。结论:中药配方颗粒研究逐年深入,但应重视中药配方颗粒研究毒理和临床安全性评价。

Objective： To analyse the contents, methods and findings in Chinese medicine dispensing granule （CMDG） related articles which was collected by Wangfang data,VIP information and CNKI in 2001-2010. Method： CMDG related articles in the three Chinese full-text database were retrieved and divided into nine categories： CMDG preparation process, chemical analysis （identification of the active ingredient, quality control, etc. ） , pharmacodynamics, toxicology, clinical safety evaluation, reporting, review and others, the number of these articles was counted at the same time. Result： The number of CMDG articles increased at first and then decreased, the peak appeared in 2007. The number of CMDG chemical research of CMDG is the most, followed by clinical applications and reports, then the pharmaceutical technology and pharmacodynamies studies, research of CMDG toxic and clinical safety is the least. Conclusion： Study of the CMDG tends to be more and more profound, and should pay more attention to the toxicology and clinical safety evaluation.