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超抗原SEA靶向治疗肿瘤途径的研究进展

Progress in the study on targeted tumor therapy of superantigen SEA
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摘要 超抗原具有强大的免疫活化作用,极低浓度即可激活大量淋巴细胞克隆.SEA是目前研究最广泛的超抗原家族之一,但单用SEA有明显的毒副作用,联合单克隆抗体治疗时单克隆抗体制备又困难,导向定位也不理想.随着肿瘤基因治疗的快速发展,研究发现采用PCR技术扩增出SEA 基因片段,借助基因载体转染肿瘤细胞,能提升SEA治疗肿瘤的靶向性和安全性,但以往基因载体的基因转载率低、安全性有待改进,纳米载体的出现为SEA靶向治疗肿瘤提供了安全保障,尤其是白蛋白纳米材料具有基因转载率高、可生物降解、生物兼容性好等特点,能更好地向靶部位输送目的基因,具有广泛的应用前景.携带超抗原SEA基因的白蛋白纳米载体有望高效安全地将SEA基因靶向导人肿瘤细胞,提高肿瘤细胞的转染率,起到靶向治疗肿瘤的作用.
作者 徐峰(综述) 李晓欣(综述) 李怀富(审校)
机构地区 珠海中山大学附属第五医院泌尿外科
出处 《国际泌尿系统杂志》 2011年第1期45-48,共4页 International Journal of Urology and Nephrology
关键词 肿瘤 抗原
分类号 R73 [医药卫生—肿瘤]
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参考文献25

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国际泌尿系统杂志
2011年 第1期

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