异甘草酸镁治疗慢性乙型肝炎的临床疗效观察

Clinical research magnesium isoglycyrrhizinate in the treatment of chronic hepatitis B

目的观察异甘草酸镁在慢性乙型肝炎患者治疗中的临床疗效。方法将60例患者随机分组,异甘草酸镁组(治疗组)30例,甘草酸二胺组(对照组)30例,分别观察两组患者治疗前后肝功能指标。结果异甘草酸镁较甘草酸二胺更快地降低ALT、TBIL水平,有利于肝功能的恢复,两组有统计学意义(P<0.05)。结论异甘草酸镁在慢性乙型肝炎的临床治疗中疗效优于甘草酸二胺。

Objective To observe the clinical efficacy of magnesium isoglycyrrhizinate in the treatment of chronic hepatitis B. Methods 60 patieats with chronic hepatitis B were randomly divided into treated group and control group. Treated group included 30 patients, were treated with 150 mg magnesium isoglycyrrhizinate added into 100 ml 5% glucose injection liquid. Control group included 30 patients ,were treated with 150 mg diammonium glycyrrhizinate added into 100 ml 5% glucose injection liquid. Results The level of ALT, AST and TBIL dropped more rapidly than that in contrust group and there were significant difference in symptoms recover＂ between treated group and control group （ P 〈 0.05 ）. Conclusion Magnesium isoglycyrrhizinate can better improve hepatitis sufferers＇ symptom and liver functions than diammonium glycyrrhizinate in the group of chronic hepatitis B.