雌激素对绝经后妇女冠心病心绞痛的疗效研究

The antianginal effects of estrogen on postmenopausal women with coronary heart disease

目的：探讨雌激素对绝经后妇女冠心病心绞痛治疗影响。方法：观察门诊42例绝经2年以上的冠心病心绞痛病人，随机分两组，除按常规用药后另在其中一组（ERT组）并用雌激素制剂，定期随访病人及检测血清性激素和血脂的改变。结果；治疗组的血清性激素各项水平均较正常对照组低（P＜0.01），替代治疗后，ERT组的激素水平可见有较明显的改变，同时心绞病症状、运动负荷耐受量也有相应增加（P＜0.01），血脂中LDC降低、HDC升高（P＜0.05）。结论：绝经后妇女的冠心病心绞痛，相应适当补充缺乏的外源性雌激素对症状的控制有一定帮助。

Objective: To investigate the antinginal effects of estrogen on postmenopausal women with coronary heart disease (CHD). Methods : 42 cases of postmenopausal women with angina pectons of CHD were selected and classifiec randomly into the estrogen replacement therapy group (ERT. 22cases ) and the no estrogen replacement therapy group (nERT,20 cases ). All Objects were under routine treatment and were followed up by regular visit, and the serum level of hormones (E2, Pro, FSH, LH) and the plasma level of lipids (TC, TG, HDC, LDC) were determined . Results: The levels of E2 and Pro were lower (P < 0. 01 ), but The levels of TG, TC and LDC were much higher than the experiment group (P < 0. 05). After a short-term estrogen administration, the level of HDC was increased and LDC was decreased,The relieved rate ot symptom of angina pectons was 66.7 % and the exercise tolerance was improved (P <0. 01 ). Conclusions: The short - term estrogen administration could relieve the symptom of angina pectons,and could improve the ECG signs of myocardial ischemia and the exercise tolerance of postmenopausal women patients .