摘要
目的探讨HSP60基因在白血病患者中的表达水平,并分析其与临床特征的关系。方法应用实时荧光定量R-PCR方法检测HSP60基因在白血病耐药组、敏感组及正常组中的表达水平并加以比较。结果 HSP60mRNA在白血病组的表达明显高于正常组,在耐药组明显高于敏感组,在ALL和AML患者中的表达没有明显差异。结论 HSP60基因有可能为新的白血病耐药相关基因。
Objective To investigate the expression level of gene HSP60 of patients with leukemia and the correlation with clinical features.Methods The expression level of gene HSP60 in drug-resistant,drug-sensitive patients of leukemia and healths were detected by real-time quantitative RT-PCR and compared each other.Results The expression of HSP60 gene in drug-resistant group higher than drug-sensitive group,in AL group higher than the healthy group,and it had nothing to do with FAB typing.Conclusion Gene HSP60 maybe a new multidrug resistant related gene.
出处
《当代医学》
2011年第3期44-45,共2页
Contemporary Medicine
