硬化剂和组织胶在治疗食管胃底静脉曲张中的疗效观察

Comparing the curative effects of sclerotherapy and injection of cyanoacrylate in esophageal and gastric varices

目的评估内镜下注射硬化剂(鱼肝油酸钠或聚桂醇)与组织黏合剂治疗食管胃底静脉曲张的近期及远期疗效。方法对278例内镜下介入治疗的食管胃底静脉曲张患者的临床资料进行回顾性分析,分为鱼肝油酸钠治疗组、聚桂醇治疗组与组织黏合剂治疗组。结果聚桂醇治疗组与鱼肝油酸钠组、组织黏合剂治疗组的止血成功率、近期及远期再出血率进行组间比较,P>0.05,差异无统计学意义。硬化剂与组织黏合剂治疗组静脉曲张改善有效率和并发症发生率比较,差异具有统计学意义(P<0.05)。结论聚桂醇在有效消除静脉曲张及并发症发生方面优于鱼肝油酸钠与组织黏合剂。

Objective To evaluate the recent and long-term curative effects of endoscopic variceal sclerotherapy（sodium morrhuate or lauromacrogol） and endoscopic injection of cyanoacrylate in esophageal and gastric varices.Methods The clinical data of 278 cases endoscopic treatment were analyzed retrospectively,and the curative effects were compared in endoscopic variceal sclerotherapy（sodium morrhuate or lauromacrogol） and endoscopic injection of cyanoacrylate.Results There were no significant differences in short and long term therapeutic efficacy among the three groups（P0.05）.The rates of effectively eliminate varices and complications were significantly differences among the three groups（P0.05）.Conclusion Endoscopic variceal sclerotherapy and injection of cyanoacrylate can effectively stanch and prevent rebleeding.Lauromacrogol are obviously superior to the sodium morrhuate and cyanoacrylate in effectively eliminate varices and complications.