舒泰麻醉老虎之不良反应二例

Adverse Reactions of Two Tigers Anaesthetized by Zoletil

舒泰是一种新型分离麻醉剂,曾在犬猫临床上使用多年,舒泰的诱导时间短,在经肌肉和静脉途径注射时,具有良好的局部耐受性。但是,在使用舒泰对1只雄性孟加拉虎和1只雌性东北虎进行麻醉的案例中,2只虎均在麻醉4 d后出现四肢僵硬,无法站立,大便糊状等症状。使用肌肉注射头孢塞肟钠、地塞米松、维生素和盐酸纳洛酮治疗,3～4 d后痊愈。我们曾用舒泰麻醉黑猩猩、赤猴、山魈、金钱豹、猎豹、非洲狮,均未出现不良反应。2只虎出现的不良反应目前原因不明。因此,使用舒泰进行麻醉时应注意以下事项:动物最好先禁食禁水12 h再麻醉;麻醉前10 min,可先肌肉注射阿托品以抑制唾液分泌;麻醉过程中和麻醉后,注意监测动物的体温、心跳和呼吸频率等体征;不要与乙酰丙嗪、氯丙嗪等吩噻嗪类药物和氯霉素合用。

Zoletil,an anesthetic,has been used on dogs and cats for many years.Zoletil has a shorter induction time and good local tolerance when injected through muscle or vein.However,in two cases,when Zoletil was used on two tigers,a male Bengal Tiger and a female Siberian tiger,both tigers showed symptoms including limb stiffness and fuzzy stool four days following injection.The two tigers were treated with Cefotaxime Sodium,dexamethasone,vitamin and naloxone hydrochloride by muscle injection and subsequently recovered in 3 or 4 days.Zoletil was used to anaesthetize chimpanzee,red monkey,mandrill,leopard, cheetah and African lion and none of these species showed adverse reactions.The reason for adverse reactions in tigers is still unknown.When using Zoletil to anesthetize,we recommend withdrawal of food and water 12 hours before anaesthetizing, injecting atropine 10 minutes before anaesthetizing to restrain saliva,monitoring body temperature,heart beat and breath during and after anaesthetizing.Zoletil should not be used together with phenothiazine drugs such as Acetyl Oxaprozin and Chlorpromazine or Chloromycetin.