不同病理特征的食管癌患者外周血肿瘤标记物浓度变化比较

Pathological features of esophageal cancer patients with different blood concentrations of tumor markers in comparison

目的:比较不同病理特征的食管癌患者外周血肿瘤标记物浓度变化。方法:连续选择接受手术治疗的食管癌患者49例,治疗前进行血清癌胚抗原(CEA)和角蛋白19片段(Cyfra21-1)标本采集,并根据手术切除标本的病理特征进行分组,比较肿瘤标记物浓度变化。结果:具有中、低程度分化、浸润肌层、淋巴结转移和瘤体≥5cm病理特点的食管癌患者血清CEA和Cyfra21-1浓度值均明显高于高分化、浸润外膜无淋巴结转移和瘤体<5cm患者(P均<0.05或0.01)。结论:食管癌患者的肿瘤细胞分化程度、瘤体大小、浸润程度及有无淋巴结转移等病理表现与外周血CEA和Cyfra21-1浓度值密切相关。

Objective：To compare the pathological features of esophageal cancer patients with different blood concentrations of tumor markers.Methods：Selected 49 patients undergoing surgery for esophageal cancer,patients before treatment serum carcinoembryonic antigen（CEA） and cytokeratin 19 fragment（Cyfra21-1） specimen collection,and according to the pathological features of resected specimens were grouped to compare tumor markers concentration changes.Results：Esophageal cancer patients with the low degree of differentiation,myometrial invasion,lymph node metastasis and patholog ical features of tumor ≥5 cm,CEA and Cyfra21-1 levels were significantly higher than well-differentiated,infiltrating the outer membrane without lymph node metastasis and tumor5 cm patients（P0.05 or 0.01）.Conclusion：The esophageal cancer cell differentiation,tumor size,depth of invasion and lymph node metastasis and other pathological manifestations are closely related with peripheral blood CEA and Cyfra21-1 concentrations.