复方丹参滴丸对冠心病患者血浆C-反应蛋白的影响

Effects of compound Danshen dripping pills on serum C-reactive protein in patients with coronary artery disease

目的:探讨复方丹参滴丸对冠心病患者血浆C-反应蛋白的影响。方法:收集116例冠心病患者,随机给予小剂量(4粒,每天三次)和大剂量(8粒,每天三次)复方丹参滴丸,分别于治疗前、治疗后第1个月、第6个月检测血浆C-反应蛋白水平。同时收集40例冠心病患者给予安慰剂(4粒,每天三次)作为对照组。结果:三组患者治疗前血浆C-反应蛋白水平无明显差别;治疗第1个月后,复方丹参滴丸治疗组患者血浆C-反应蛋白较对照组下降(P<0.05),大剂量组和小剂量组间不明显差别;治疗第6个月后,复方丹参滴丸组血浆C-反应蛋白进一步下降,大剂量组较小剂量组下降更明显,差别具有统计学意义(P<0.05)。结论:复方丹参滴丸能够下调冠心病患者血浆C-反应蛋白水平,且呈剂量依赖性。

Objective： To investigate effects of compound Danshen Dripping Pills on serum C-reactive protein in patients with coronary artery disease. Method： We enrolled 116 patients with coronary artery disease and randomly prescribed with low dose compound Danshen dripping pills （4 pills, three time per day） and high does compound Danshen dripping pills （8 pills, three time per day）, and we evaluated serum C-reactive protein level at pre-treatment, 1 month post-treatment and 6 months post-treatment. Concomitantly, 40 patients with coronary artery disease as control group were prescribed with placebo. Results： There were no difference among 3 groups before treatment, while at 1 month post-treatment serum C-reactive protein level in compound Danshen dripping pills were significantly reduced compared with control group （P〈0.05） and there was no difference between low dose and high dose group. At 6 month post-treatment, serum C-reactive protein level were filrther reduced in both compound Danshen dripping pills groups and the reduction in high dose group was more significant than low does group （P〈0.05）. Conclusion： Compound Danshen dripping pills could down-regulate serum C-reactive protein level in patient with coronary artery disease and the effect correlated with prescribed dose.