介入疗法治疗肝癌502例报告

A Report of Interventional Therapeutic Method in the Treatment of 502 Cases of Hepatic Carcinoma

顺铂（ Ｃ Ｄ Ｄ Ｐ） 和阿霉素（ Ａ Ｄ Ｍ） 已越来越多地用于肝癌的局部灌注化疗或化疗栓塞（ 和碘化油及明胶绵联合） ，取得了比较满意的效果。为了比较两种药物的治疗效果，对我院１９８８ 年至１９９５ 年收治的５０２ 例原发性肝癌分别用顺铂治疗３７６ 例，阿霉素治疗１２６ 例。结果示：⑴顺铂治疗组：局部化疗１７１ 例，有效（ 完全缓解＋ 部分缓解）１４５ 例，平均生存期１２７ 月；化疗栓塞２０５ 例，肿瘤坏死率８８ ％ ，平均生存期２８５ 月；⑵阿霉素组：局部化疗６６ 例，有效４３ 例，平均生存期９５ 月；化疗栓塞６０ 例，肿瘤坏死率５５ ％ ，平均生存期２０５ 月。两组比较，顺铂治疗组明显优于阿霉素组（ Ｐ ＜ ００１） 。

The 163 Central Hospital of P.L.A Changsha 410003 Cisplatin (CDDP) and Adriamycin (ADM) were extensively used as anticancer drugs and had good efficacy in the treatment of hepatic carcinoma.In the study,from 1988 to 1995,502 cases of progressive hepatic carcinoma had received 1578 times of hepatic arterial infusion and embolization.The comparison of curative effects for the two drugs were as follows:⑴In 376 cases treated by CDDP(CDDP group),171 cases were treated with hepatic arterial infusion chemotherapy,in which 145 cases had an effective response (complete regression and partial regression) and the mean survival time was 12 7 months.205 cases treated with hepatic arterial chemoembolization (combined with lipiodol oil and gelatin sponge embolization),the tumor necrosis rate was 88% and the mean survival time was 28.5 months.⑵In 126 cases with ADM treatment (ADM group),66 cases were treated with hepatic regional infusion chemotherapy,in which 43 cases had an effective response and the mean survival time was 9.5 months.The tumor necrosis rate of 60 cases treated with hepatic arterial chemoembolization was 55% and the mean survival time was 20.5 months.The results suggest that the efficacy of CDDP was better than those with ADM(P<0 01).