乌龙丹治疗急性脑梗死的临床疗效及其经颅彩色多普勒超声分析

Observations on clinically curative effects and analysis of transcranial colour Doppler in treatment with Wulong Pill(乌龙丹) for acutely cerebral infarction

目的：观察乌龙丹治疗急性脑梗死的临床疗效及其经颅彩色多普勒超声（ＴＣＤ）检测结果。方法：治疗组３５ 例，用药为乌龙丹＋ 低分子右旋糖酐＋ 尼莫通，对照组３１ 例用低分子右旋糖酐＋ 尼莫通，治疗前后做ＴＣＤ检查和疗效评分。结果：用药４ 周后，治疗组总有效率（９７１％ ）显著优于对照组（８７１％ ，Ｐ＜ ００５），疗效评分值〔（２４１８±３１４）分〕明显增高〔对照组为（２１６５±３５１）分，Ｐ＜ ００１〕；治疗前，大脑前动脉（ＡＣＡ）、大脑中动脉（ＭＣＡ）、椎动脉（ＶＡ）、基底动脉（ＢＡ）均有血流速度减低，部分患者大脑两侧血流速度不对称（左右差值＞ ２０ ｃｍ ／ｓ），频谱形态异常或欠清晰。治疗４ 周后，２ 组患者的ＴＣＤ均有不同程度改善，以治疗组改善较显著，而对照组的ＶＡ、ＢＡ 改善不明显。结论：乌龙丹加低分子右旋糖酐和尼莫通治疗急性脑梗死疗效优于低分子右旋糖酐和尼莫通的治疗，并对梗死期出现的脑血流速度减慢。

Objective:To observe the clinically curative effects of Wulong Pill(乌龙丹) on acutely cerebral infarction (ACI) and changes in transcranial colour Doppler (TCD).Methods:The treatment group(35 cases)was treated with Wulong Pill+low molecular weight dextran+nimoton while the control group(31 cases) treated with low molecular weight dextran+nimoton only.Before and after therapy the examination of TCD and scores of curative effects were carried out.Results:In 4 weeks using drugs the total effective rate (97 1%) in treatment group was significantly superior to that (87 1%) in control group and the scores of curative effects were significantly increased 〔(24 18±3 14) scores vs.(21 65±3 51) scores, P <0 01〕.Before therapy the speed of blood flows in anterior cerebral artery (ACA),middle cerebral artery (MCA),vertebral artery (VA),and basilar artery (BA) was slowed down and in partial patients the speed of blood flows in two sides of brain was not symmetry (different value >20 cm/s).The morphology of frequent spectrum was abnormal and unclear.After 4 weeks therapy the TCD for both two groups had improvements in different extent and the improvements in treatment group was more significant otherwise in control group the improvements in VA and BA were not obvious.Conclusions:The curative effects of Wulong Pill+low molecular weight dextran+nimoton on ACI are superior to those of low molecular dextran+nimoton only.The treatments with former drugs possess better improving actions on slowed speed of blood flows and qualitative change in blood flows even occlusion occured during infarction phase.