摘要
目的：探讨破瘀通脉散治疗脑梗死的作用及可能机制。方法：用破瘀通脉散治疗３０ 例急性脑梗死患者（复方组），与３０ 例单用低分子右旋糖酐加胞二磷胆碱治疗组（西药组）进行对比，观察神经功能缺损程度和血浆谷胱甘肽过氧化物酶（ＧＳＨ Ｐｘ）、内皮素（ＥＴ）含量变化。结果：复方组总有效率为９６６７％ ，总显效率６０００％ ，疗效优于西药组（分别为８６６７％ 和３３３３％ ，Ｐ均＜ ００５）。患者血浆ＧＳＨ Ｐｘ 含量升高，ＥＴ含量下降，其神经动能缺损程度的改善较西药组显著。结论：破瘀通脉散对脑梗死有治疗作用，其机制可能为提高组织清除自由基能力、抑制ＥＴ生成与释放。
Objective:To investigate the actions and possible mechanisms of Poyu Tongmai Powder(PYTMP,破瘀通脉散) on treating cerebral infarction.Methods:30 patients with acutely cerebral infarction (complex prescription group)were treated with PYTMP while 30 cases with acutely cerebral infarction (western medicine group)treated with low molecular weight dextran plus citicoline and the comparison between two groups was carried out.The degree of nervous functional defects and the changes in concentrations of plasma(GSHPx) and endothelin (ET) were observed.Results:In complex prescription group the total effective rate (96 67%) and total markedly effective rate (60 00%) were superior to those (86 67%) and (33 33%) respectively in western medicine group furthermore the concentration of GSHPx was increased but the concentration of ET decreased and the improvement of degree of nervous functional defects was more significant than that in western medicine group.Conclusions:PYTMP possesses therapeutic effects on cerebral infarction and the mechanisms may be that it is able to enhance the tissue ability to eliminate free radicals and to inhibit formation and release of ET.
出处
《中国中西医结合急救杂志》
CAS
1999年第9期421-423,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
上海市卫生局科研基金
