口腔颌面外科手术麻醉时异丙酚和硫喷妥钠临床效应的比较

The clinical analysis of propofol anesthesia in oral maxillofacial surgery.

目的 观察异丙酚用于口腔颌面外科手术麻醉时对循环、呼吸及苏醒的影响，并与传统药物硫喷妥钠相比较。方法 选择颌骨切除手术３０ 例，随机分为两组（异丙酚组和硫喷妥钠组），比较注药前后循环、呼吸等变化。结果 异丙酚对循环的影响比硫喷妥钠小，但呼吸暂停的发生率高于硫喷妥钠（ Ｐ＜ ００１），唤醒时间明显短于硫喷妥钠（ Ｐ＜ ００１）。结论 异丙酚副作用少，苏醒迅速，用于口腔颌面外科等长时间的手术，安全有效。

Objective To compare the effects of propofol with traditional thiopental anesthesia for oral maxillofacial surgery in terms of vital sign changes and awakening time.Methods Thirty cases undergoing maxillectomy were randomly divided into two groups(propofol and thiopental) in order to compare vital sign changes before and after administration of anesthetics(propofol and thiopental).Results The pharmacological circulatory disturbance of propofol was less important than thiopental and the incidence of apnea was significantly higher than thiopental( P <0.01).The awakening time of propofol was significantly shorter than thiopental( P <0.01).Conclusion With rapid awakening time and few side effects,propofol is a safe anesthetic agent in oral maxillofacial surgery,especially for long time operation.