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外周T细胞淋巴瘤治疗新药普拉曲沙的药理及临床评价 被引量：5

Pharmacology and clinical evaluation of pralatrexate for treatment of peripheral T-cell lymphoma
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摘要 普拉曲沙为首个治疗外周T细胞淋巴瘤(peripheral T-cell lymphoma,PTCL)药物,适用于复发或对其他化疗药物治疗无效的PTCL患者。本文通过检索文献,对普拉曲沙的作用机制、药动学、药理作用、临床评价及不良反应等方面进行了综述,为临床用药提供参考。 Pralatrexate is the first drug for treatment of peripheral T-cell lymphoma（PTCL）.It has been used in patients with recrudescence or without response to other chemotherapies.This review summarized its mechanisms of action,pharmacology,pharmacodynamics,clinical evaluation and adverse reactions in order to provide a reference for clinical medication.
作者 戴一
机构地区 安徽新华学院药学院
出处 《中国新药杂志》 CAS CSCD 北大核心 2011年第2期97-100,共4页 Chinese Journal of New Drugs
关键词 普拉曲沙 外周T细胞淋巴瘤 药理作用 临床评价 pralatrexate peripheral T-cell lymphoma（PTCL） clinical pharmacology clinical evaluation
分类号 R979.1 [医药卫生—药品]
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参考文献13

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同被引文献14

  • 1丁梦杰,张明智.外周T细胞淋巴瘤治疗进展[J].中国实用医刊,2010,37(9):58-60. 被引量：2
  • 2Fisher RI,Gaynor ER,Dahlberg S,et al.Comparison of a standard regimen(CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma[J].N Engl J Med,1993,328(14):1002 - 1006.
  • 3Riley K.FDA approves first drug for treatment of peripheral T-cell lymphoma[J].Mol Cell Pharmacol,2009,1 (4): 230 - 232.
  • 4Hanauske AR,Eismann U,Oberschmidt O,et al.In vitro chemosensitivity of freshly explanted tumor ceils to pemetrexed is correlated with target gene expression[J]. Invest New Drugs,2007,25(5)'417 - 423.
  • 5Takamatsu Y, Suzumiya J,Utsunomiya A,et al.THP-COP regimen' for the treatment of peripheral T-cell lymphoma and adult T-cell leukemia/lymphoma:a multicenter phase Ⅱ study[J].Eur J Haematol,2010,84(5):391 - 397.
  • 6Adjei AA.Clinical studies of pemetrexed and gemcitabine combinations[J].Ann Oncol,2006,17(Suppl 5):v29 - v32.
  • 7Raizer JJ,Rademaker A,Evens AM,et al.Pemetrexed in the treatment of relapsed/refractory primary central nervous system lymphoma[J].Cancer,2012,118(15):3743 - 3748.
  • 8王青,倪晓慧.1例皮下脂膜炎性T细胞淋巴瘤病人的护理[J].全科护理,2011,9(34):3205-3206. 被引量：1
  • 9陆艳红,许丹,张旭辉.肿瘤患者化疗所致口腔黏膜炎的预防与护理[J].中国医药指南,2012,10(18):339-340. 被引量：6
  • 10李静敏(综述),王华庆(审校).外周T细胞淋巴瘤的治疗进展[J].中国肿瘤临床,2016,43(4):166-169. 被引量：9

引证文献5

二级引证文献2

中国新药杂志
2011年 第2期

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