有机硫类抗真菌药物的研究进展

Progress in the study of organosulfur antifungal drugs

抗真菌药物(antifungal drugs)是一种用于治疗真菌感染的有效药物。近年来,天然抗真菌化合物的筛选和合成抗真菌药物的结构修饰促进了有机硫类抗真菌药物迅速发展。文中对天然有机硫类抗真菌化合物的研究进展进行了综述,同时从氮唑类、硫脲类和丙烯胺类以及硫色酮类等3类化合物的结构修饰方面综述了目前合成有机硫类抗真菌药物的研究进展。

Antifungal drugs are effective in the treatment of fungal infections.In recent years,the screening of natural antifungal compounds and structural modification of synthetic antifungal agents promote the rapid development of organosulfur antifungal drugs.The progress in the study of natural organosulfur antifungal agents and the development of the synthetic organosulfur antifungal drugs on the structural modification of azoles,thioureas and allylamines,thiochromones were reviewed.