兔脑栓塞后不同时间溶栓治疗的疗效及安全性研究

Delayed UK therapy in a rabbit model of thromboembolic stroke

通过兔颈内动脉梗塞模型评价不同时间给予UK溶栓治疗的疗效和安全性。发现栓塞后0．5、2、4、6h溶栓治疗组与相应的对照组的梗塞灶占半球的百分率分别为2．60±1.40％／38．36±4．01％（P＜0．001）、11．96±3．12％／38．10±3．43％（P＜0．001）、27．13±5．95％／39．06±4．02％（P＜O．01）、38．220±498％／37.77±3．18％（P＞0．05）。栓塞后0．5、2h溶栓治疗组未见脑出血．4、6h组部分动物见脑出血。提示兔脑栓塞后早期给予UK治疗可缩小脑梗塞体积，减少脑损害；过迟溶栓治疗不能缩小梗塞灶，且有增加脑出血的危险。

To evaluate the efficacy and safety of delayed therapy with urokinase in a rabbit model ofthromboembolic stroke. The mean infarct size of groups treated with urokinase O. 5、2、4, 6hours after em-bolization and control groups were 2. 60±1. 40% /38.36±4.01% (P <0.001)、 11.96±3.12 % /38.10±3. 43% (P <0.001)、27.13±5. 95%/39.06±4.02% (P<0.01)、38. 220±4. 98%/37. 77±3.18% (P>0.05 ). No cerebral hemorrhage was found in the groups treated with urokinase at 0.5, 2h after em-bolization, there were brain hemorrhage animals in the 4、6houres delayed therapy groups. It indicatedthat early administration of urokinase could reduce the infarct size and improve the clinical outcome. the in-farct size couldn't be reduced when urokinase therapy delayed longer and probaboy increased the risk ofhemorrhagic transformation.