阿奇霉素治疗小儿支原体肺炎的随机对照研究

The RCT Clinical Study of Azithromycin′s Curative Effect on Young Child Mycoplasma Pneumonia

目的研究阿奇霉素治疗小儿支原体肺炎的临床效果。方法将259例2007年1月—2010年1月我院儿科接受住院治疗的支原体肺炎患儿随机分成治疗组和对照组,治疗组在一般治疗及对症治疗基础上给予阿奇霉素10mg/(kg.d),用5%葡萄糖溶液稀释后静脉滴注,1次/d,疗程为5～7d。对照组在一般治疗及对症治疗基础上每天给予红霉素30mg/(kg.d),用5%葡萄糖溶液稀释后缓慢静脉滴注,1次/d,疗程为1～2周。结果治疗组的有效率为93.85%,对照组的有效率为86.05%,两组比较差异有统计学意义(P<0.05);治疗组的不良反应发生率与对照组不良反应发生率比较差异有统计学意义(P<0.05)。结论阿奇霉素治疗小儿支原体肺炎治愈率高而不良反应的发生率比较低,值得在儿科支原体肺炎患者中推广应用。

Objective Observe the curative elect of azithromycin on the young children＇s myeoplasma pneumonia. Methods The 259 young children with mycoplasma pneumonia who were hospitalized in our hospital＇s pediatric ward from Jan 2007 to Jan 2010 were randomly divided into treatment groups and control groups, besides treated with the ordinary therapeutical Methods , the treatment group were given azithromycin 10mg/ （kg·d） , qd, continued for 5 -7 days, and the control group were given erythromyci 30mg/ （kg ·d） , qd, continuted for 1 -2 weeks. Results The treatment group＇s curative efficacy rate was 93.85% , and the control group＇s efficacy rate was 86. 05% , compared with the control group, there is significant statistical difference （P 〈0. 05）; compared with each other, the two group＇s adverse recation also has significant statistical difference （ P 〈 0. 05 ）. Conclusion Azithromycin＇s treatment of young child with mycoplasma pneumonia has a higher curative rate and lower incidence of adverse reactions, and it is worthy ofbeing widely applied in clinical practice.