血压控制对慢性心力衰竭急性加重患者近期临床疗效的影响

Effect of blood pressure level control on clinical manifestation,short-term outcome in patients with acute attack of chronic heart failure

目的：探讨血压控制水平对慢性心力衰竭（CHF）急性加重患者临床疗效的影响。方法：在规范治疗的基础上，根据收缩压控制水平将192例CHF患者分为低血压水平组（80～100mmHg）、中血压水平组（101～120mmHg）和高血压水平组（121～140mmHg），观察不同血压水平CHF患者的临床疗效。结果：显效、有效和无效／恶化率在低血压水平组分别为46．8％（29／62）、45．2％（28／62）和8．1％（5／62），中血压水平组为27．3％（18／66）、54．5％（36／66）和18．2％（12／66），高血压水平组为12．5％（8／64）、50．0％（32／64）和37．5％（24／64）。结论：CHF患者急性加重时血压水平在一定范围内控制越低，临床症状改善越快，近期疗效越好。

Objective：This study sought to explore the effect of blood pressure （BP） level control on the short-term clinical efficacy in patients with acute attack of chronic heart failure （CHF）. Methods：According to the BP level controlled, a cohort of 192 consecutive cases with acute attack of CHF was assigned to three groups, namely, lower BP level control group （systolic BP, 80-100 mmHg）, middle BP level control group （systolic BP, 101 120 mmHg）, and higher BP level control group （systolic BP, 121-140 mmHg）. The clinical manifestation and short-term prognosis were observed and analyzed. Results：The excellence rate, efficacy rate and inefficacy/deterioration rate were 46.8% （29/ 62）, 45.2% （28/62） and 8.1% （5/62） in lower BP level control group ; 27.3% （18/66）, 54.5% （36/ 66） and 18.2% （12/66）in middle BP level control group; 12.5% （8/64）, 50.0% （32/64） and 37.5% （24/64） in higher BP level control group, respectively. Conclusion： To certain extent, the lower BP level is associated with the faster relief of the clinical symptoms and the better short-term efficacy in patients with abruptly aggravated CHF.