脑梗死血清可溶性内皮细胞白细胞粘附分子-1的变化

Change of Serum Soluble Endothelial Leukocyte Adhesion Molecule 1 in Patients with Cerebral Infarction

目的 探讨急性脑梗死血清可溶性内皮细胞白细胞粘附分子－１（ｓＥＬＡＭ－１）的变化及其临床意义。方法 采用ＥＬＩＳＡ测定了６９ 例脑梗死患者血清ｓＥＬＡＭ－１的变化，并与２３ 例脑出血和２０ 例正常人对照比较。结果 脑梗死患者２４ ｈ 内血清ｓＥＬＡＭ－１ 水平明显高于脑出血和正常对照组（Ｐ＜ ０．０１）。血清ｓＥＬＡＭ－１ 水平在２４ｈ 至１４ 天（ｄ）呈下降趋势。大梗死灶组血清ｓＥＬＡＭ－１ 水平明显高于中、小梗死灶组。脑梗死后并发感染者血清ｓＥＬＡＭ－１ 水平明显升高。结论 ｓＥＬＡＭ－１ 与急性脑梗死密切相关，深入研究ｓＥＬＡＭ－１

Objective The aim of this study is to characterize the pattern of release of soluble endothelial leukocyte adhesion molecule 1(sELAM 1) in patients with acute cerebral infarcion and its clinical significance. Methods The level of serum sELAM 1 was measured with enzyme linked immunosorbent assay (ELISA) in 69 patients with acute cerebral infarction, 23 patients with cerebral hemorrhage and 20 normal controls. Results It showed that the level of serum sELAM 1 in patients with cerebral infarction 24 hours after the onset was higher than that in patients with cerebral hemorrhage and in normal controls (P<0.01). The level of serum sELAM 1 in patients with cerebral infarction was decreased from 24 hours to 14 days. The level of serum sELAM 1 is significantly higher in the patients with large cerebral infarction than that in patient with medium and small cerbral infarction. The level of serum sELAM 1 was higher in patients with infection as compared with those without. Conclusion The finding suggested that sELAM 1 is closely related to the development of cerebral infarction.