左磷右胺盐母液黏度测定与关联

Determination and correlation of mother liquor viscosity of R-(+)-α-phenethylammonium.IR.2S-(-)-cis-1,2-epoxypropyl phosphonate

在液体混合物黏度理论的基础上,选取适宜的黏度方程,通过对左磷右胺盐[(±)2顺21,22环氧丙基磷酸(±)苯乙胺]母液组分分析和黏度测定,关联得到了左磷右胺盐(左盐)母液和水、乙醇的黏度理论计算公式,并将所得黏度的计算结果和实验结果进行比较,结果表明:该黏度理论计算公式与含少量水的体系实验测定关联结果较好,对含水量较多体系的实验测定结果存在一定的误差。黏度测定实验结果还表明,乙醇和一定量的水均能有效降低母液黏度,为化学生产磷霉素钠的工程应用提供了一种简便途径。

The mother liquor components and viscosity of R-（＋）-α-phenethylammonium.IR.2S-（-）-cis-1,2-epoxypropyl phosphonate were analyzed on the basis of the liquid mixtures viscosity theory.With the proper viscosity equations,the theoretical calculation formula of mother liquor viscosity of R-（＋）-α-phenethylammonium.IR.2S-（-）-cis-1,2-epoxypropyl phosphonate with ethanol or water was obtained.The calculated viscosity was compared with the experimental results.It shows that the theoretical viscosity calculation formula is well correlated with the systems containing a little water,but has some deviation with the system containing more water.The result also reveals that ethanol and a certain amount of water can efficiently reduce the viscosity of mother liquor,which supplies a simple and convenient way for engineering application in the chemical production of fosfomycin sodium.