40名健康青年女性乳腺组织不同回波时间的~1H-MRS分析

Proton ~1H MR Spectroscopy of Breast Tissues with Different Echo Time

目的探讨MR在不同回波时间（echo times,TE）对正常乳腺组织胆碱复合物（Cho）氢质子磁共振波谱（1H-MRS）的影响,为研究正常乳腺及乳腺疾病的诊断和鉴别诊断提供客观依据。资料与方法选择40名健康未婚青年女性自愿者,平均年龄（21.4±2.4）岁（20~24岁）,所有自愿者均行常规MRI,在其基础上选择感兴趣区（ROI）并行二维1H-MRS检查,TR为1500ms,TE分别为80ms、110ms、135ms、270ms,分析不同TE下健康青年女性的正常乳腺组织的1H-MRS图形,并对比不同TE是否出现Cho峰和对Cho峰阳性率的影响。结果 TE为80ms时,探测到可辨认的Cho峰阳性率为15.0%（6/40）;TE为110ms,阳性率17.5%（7/40）;TE为135ms时,阳性率20%（8/40）;TE为270ms时,阳性率17.5%（7/40）,各阳性率之间差异无统计学意义（P（0.05）;在乳腺的1H-MRS检查中,TE在110~270ms之间为探测Cho峰的最佳TE。结论 Cho峰在健康青年女性少部分乳腺组织中可探及,但仅表现为低振幅;随着TE的延长,探测到Cho峰的可能性越大,其临床应用价值有待进一步研究。

Objective To explore the choline contents in the normal breasts of healthy young woman with different echo times（TE）,in order to offer the objective evidence for the diagnosis and differential diagnosis of normal breasts or breast lesions.Materials and Methods Forty unmarried young women were selected as health volunteers with the average age of 21.4±2.4（20-24 years old）.All volunteers underwent conventional MRI scan and 2D 1H magnetic resonance spectroscopy（MRS）with different TE（80,110,135,and 270 ms）.The choline contents were calculated under different TE.Results Under TE=80 ms,the detection rate of choline identifiable peak was 15.0%（6/40）;TE=110 ms,the detection rate was 17.5%（7/40）;TE=135 ms,the detection rate was 15.0%（8/40）;TE=270 ms,the detection rate was 17.5%（7/40）.The optimization TE was 110-270 ms for detecting choline peak.Conclusion The Cho peak with low amplitude can be detected in some normal breast tissue.With increasing the echo time,the detection rate of identifiable choline peak increased.The clinical value of spectroscopy need to be studied further.