异基因造血干细胞移植中CD4^+CD25^+调节性T细胞与急性移植物抗宿主病的相关性

Correlation of CD4^+CD25^+ regulatory T cells and acute graft versus host disease in allogenic hematopoietic stem cells transplantation

背景:CD4+CD25+调节性T细胞是调节性T细胞的一个重要亚群,在诱导移植耐受方面起着重要作用。目的:综述CD4+CD25+调节性T细胞的特性、免疫调节作用机制及其与急性移植物抗宿主病的相关性。方法:应用计算机检索PubMed、Medline数据库1990-01/2010-02,维普数据库2000-01/2010-02以及运用Google网络数据库有关CD4+CD25+调节性T细胞及其他与急性移植物抗宿主病相关性研究的文献。结果与结论:CD4+CD25+调节性T细胞在异基因造血干细胞移植后产生的急性移植物抗宿主病中起着重要作用,不仅能有效预防和治疗急性移植物抗宿主病,同时还能保留移植物抗白血病效应作用。随着研究的深入,发现CD4+CD25+调节性T细胞很有希望成为急性移植物抗宿主病早期风险预测的一项重要实验诊断指标,并且有可能通过调控移植后患者体内CD4+CD25+调节性T细胞水平来预防和控制急性移植物抗宿主病的发生。但是,要将CD4+CD25+调节性T细胞应用于临床尚有问题有待解决,例如CD4+CD25+调节性T细胞细胞表面特异性标志物是什么,如何提高CD4+CD25+调节性T细胞在人体内的活性以及怎样充分发挥其免疫抑制功能等。

BACKGROUND：CD4^＋CD25^＋ regulatory T cells are one of the important subsets of regulatory T cells,playing an important role in inducing transplantation tolerance.OBJECTIVE：To summarize characteristics,immunoloregulation action mechanism of CD4^＋CD25^＋ regulatory T cells and its correlation with acute graft versus host disease.METHODS：We retrieved PubMed and Medline databases for articles published from January 1990 to February 2010,Vip Database for articles published from January 2000 to February 2010,and Google for articles concerning CD4^＋CD25^＋ regulatory T cells and acute graft versus host disease.RESULTS AND CONCLUSION：CD4^＋CD25^＋ regulatory T cells play an important role in acute graft versus host disease following allogenic hematopoietic stem cells transplantation.CD4^＋CD25^＋ regulatory T cells not only effectively prevent and treat acute graft versus host disease,while retain graft versus leukemia effect.A detailed study found that CD4^＋CD25^＋ regulatory T cells are an important experimental diagnostic indicator of acute graft versus host disease for early phase risk forecast,and possibly prevent and control the occurrence of acute graft versus host disease through regulating the level of CD4^＋CD25^＋ regulatory T cells in vivo.However,CD4^＋CD25^＋ regulatory T cells applied in clinic still have some issues to be resolved,such as what is the specific cell surface marker of CD4^＋CD25^＋ regulatory T cells,and how to improve the activity of CD4^＋CD25^＋ regulatory T cells in the human body and how to play its immunosuppressive function abundantly.