摘要
目的 研究雌激素受体α(ERα)及磷酸化ERα(p-ERα)在肝癌组织中的表达及临床意义,并探讨ERα、p-ERα表达与白细胞介素6(IL-6)之间的相关性.方法 采用免疫组化方法检测77例肝癌组织中ERα、p-ERα及IL-6的表达,并分析ERα与肝癌临床病理资料及预后之间的关系.结果 肝癌组织ERα、p-ERα以及IL-6的阳性率分别为39.0%(30/77)、45.4%(35/77)、72.7%(56/77).ERα、p-ERα表达与IL-6表达呈负相关(r=-0.468,P<0.05;r=-0.370,P<0.05).肿瘤直径≤5 cm、血清甲胎蛋白水平<400μg/L、肿瘤有完整包膜及无镜下癌栓患者ERα阳性率明显高于肿瘤直径>5 cm、血清甲胎蛋白水平≥400μg/L、肿瘤无完整包膜及有镜下癌栓患者(P<0.05).ERα阳性与ERα阴性肝癌患者术后总生存率分别为66.7%和23.4%(P<0.01),ERα阳性与ERα阴性肝癌患者术后无瘤生存率分别为83.3%和57.4%(P<0.05).结论 ERα阳性的肝癌患者肿瘤生物学特性以及预后较阴性患者好,ERα在肝癌中的作用可能与 IL-6相关.
Objective To investigate the expression and its clinical significance of estrogen receptor (ERα) and phosphorylated estrogen receptor (p-ERα) in patients with hepatocellular carcinoma. The associations between ERα, p-ERα and IL-6 were also analyzed. Methods Immunohistochemistry was used to detect the expression of ERα, p-ERα and IL-6 in tumor tissues from 77 cases with hepatocellular carcinoma. The relations between ERα and the clinical pathological parameters and prognosis were also analyzed. Results The positive rates of ERα, p-ERα and IL-6 in hepatocellular carcinoma were 39. 0% (30/77), 45.4% (35/77) and 72. 7% (56/77), respectively. The expression of ERα and p-ERα were negatively correlated with the expression of IL-6 (r= -0.468, P < 0.01; r = - 0.370, P < 0.01,respectively). The positive rate of ERα in patients with tumor size≤5 cm, serum level of alpha-fetoprotein < 400 μg/L, with complete encapsulation and non-microvascular invasion was significantly higher than those with tumor size >5 cm, serum level of alpha-fetoprotein ≥400 μg/L, non-complete encapsulation and with microvascular invasion ( all P < 0. 05). The overall survival rates of ERα-positive and ERα-negative patients were 66. 7% and 23.4% ( P <0. 05 ). And the disease-free survival rates of ERα-positive and ERα-negative patients were 83. 3% and 57. 4% (P <0. 05). Conclusions The tumor biological features of ERα-postive patients are better than that of ERα-negative patients. The role of ERα in hepatocellular carcinoma may be related to IL-6 level.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2010年第24期1875-1880,共6页
Chinese Journal of Surgery
基金
国家自然科学基金资助项目(30972893)
关键词
癌
肝细胞
受体
雌激素
白细胞介素-6
生存分析
免疫组化
Carcinoma, hepatocellular
Receptor, estrogen
lnterleukin-6
Survival analysis
Immunohistochemistry