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放射生物学若干科学问题与学科前沿 被引量：1

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摘要 实验放射生物学已经历了110年的发展历史.微束照射、基因与蛋白组学和生物信息、干细胞技术以及活细胞分子影像与实时动态成像等一系列新技术的发展应用,使得近年来放射生物学研究取得了显著进展和突破,放射生物学中很多基础研究与生命科学前沿的结合更加密切.
作者 周平坤
机构地区 军事医学科学院放射与辐射医学研究所
出处 《中华放射医学与防护杂志》 CAS CSCD 北大核心 2010年第6期629-633,共5页 Chinese Journal of Radiological Medicine and Protection
关键词 放射生物学 生命科学 干细胞技术 微束照射 生物信息 蛋白组学 动态成像 分子影像
分类号 R144 [医药卫生—公共卫生与预防医学]
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  • 1Shang YL, Bodero AJ, Chen PL. NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response. J Biol Chem 2003; 278:6323-6329.
  • 2Lou Z, Chini CC, Minter-Dykhouse K, Chen J. Mediator of DNA damage checkpoint protein 1 regulates BRCA 1 localization and phosphorylation in DNA damage checkpoint control. JBiol Chem 2003; 278:13599-13602.
  • 3Lukas C, Melander F, S tucki M, et al. Mdcl couples DNA doublestrand break recognition by Nbsl with its H2AX-dependent chromatin retention. EMBO J 2004; 23:2674-2683.
  • 4Morris JR, Solomon E. BRCA 1 : BARD 1 induces the formation of conjugated ubiquitin structures, dependent on K6 ofubiquitin, in cells during DNA replication and repair. Hum Mol Genet 2004; 13:807-817.
  • 5Yu X, Fu S, Lai M, Baer R, Chen J. BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIE Genes Dev 2006; 20:1721-1726.
  • 6Polanowska J, Martin JS, Garcia-Muse T, Petalcorin MI, Boulton SJ. A conserved pathway to activate BRCA 1-dependent ubiquitylation at DNA damage sites. EMBO J 2006; 25:2178-2188.
  • 7Ito K, Adachi S, Iwakami R, et al. N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNFS. Eur J Biochem 2001 ; 268:2725-2732.
  • 8Plans V, Scheper J, Soler M, et al. The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation. J Cell Biochem 2006; 97:572-582.
  • 9Andersen PL, Zhou H, Pastushok L, et al. Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and UevlA. J Cell Biol2005; 170:745-755.
  • 10Bothos J, Summers MK, Venere M, Scolnick DM, Halazonetis TD. The Chfr mitotic checkpoint protein functions with Ubc 13- Mms2 to form Lys63-linked polyubiquitin chains. Oncogene 2003; 22:7101-7107.

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  • 1Barker N, van Es JH, Kuipers J, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature, 2007, 449(7165): 1003-1007.
  • 2Sangiorgi E, Capecchi MR. Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet, 2008, 40(7): 915-920.
  • 3Li LH, Clevers H. Coexistence of quiescent and active adult stem cells in mammals. Science, 2010, 327(5965): 542-545.
  • 4Tian H, Biehs B, Warming S, et al. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature, 2011, 478(7368): 255-259.
  • 5Potten CS. Radiation, the ideal cytotoxic agent for studying the cell biology of tissues such as the small intestine. Radiat Res, 2004, 161(2): 123-136.
  • 6Yan KS, Chia LA, Li X, et al. The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proc Natl Acad Sci U S A, 2012, 109(2): 466-471.
  • 7George RJ, Sturmoski MA, May R, et al. Loss of p21 Waf1/Cip1/Sdi1 enhances intestinal stem cell survival following radiation injury. Am J Physiol Gastrointest Liver Physiol, 2009, 296 (2): G245-G254.
  • 8Leibowitz BJ, Qiu W, Liu HT, et al. Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. Mol Cancer Res, 2011, 9(5): 616-625.
  • 9Qiu W, Carson-Walter EB, Liu HT, et al. PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell, 2008, 2(6): 576-583.
  • 10Qiu W, Leibowitz B, Zhang L, et al. Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. Oncogene, 2010, 29(11): 1622-1632.

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中华放射医学与防护杂志
2010年 第6期

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