射频辐射对哺乳动物体细胞遗传学效应的Meta分析

Genetic effects in mammalian somatic cells exposed to radiofrequency radiation： a meta-analysis

目的 探讨射频辐射对哺乳动物体细胞的遗传学影响.方法 采用Meta分析方法,对国内外1991-2009年关于哺乳动物体细胞遗传学损伤与射频辐射暴露关系的研究文献共计46篇进行综合定量分析.结果 射频辐射暴露后,辐射组与对照组彗尾尾长的加权均数差（WMD）及95%CI为1.03（0.74,1.31）,尾距为0.10（0.04,0.16）;和对照组比较,2000 MHz以下的射频辐射组染色体畸变RR及95%CI为1.21（0.68,2.13）,大于2000 MHz组为1.76（1.05,2.97）;射频辐射与微核发生的合并RR及95%CI为1.39（1.18,1.64）;射频辐射组与对照组SCE发生数目的 WMD及95%CI为0.40（-0.33,1.14）.结论 射频辐射暴露一定程度上会加重哺乳动物体细胞DNA损伤,增加微核发生率;2000 MHz以上的射频辐射可能会引起染色体畸变率的上升,低于2000 MHz的射频辐射对染色体畸变发生无显著影响;射频辐射暴露对哺乳动物体细胞姐妹染色单体交换的发生无显著影响.

Objective To investigate the genetic effects of radio-frequency radiation （RF-radiation） on mammalian somatic cells. Methods A meta-analysis of reported data （1991-2009） was conducted to obtain a quantitative estimate of genotoxicity （ including single-and double-strand breaks in the DNA, incidence of chromosome aberration, micronuclei, and sister chromatid exchanges） in RF-radiationexposed cells compared with sham-exposed cells or unexposed control cells. Results After RF-radiation exposure, the weighted mean difference and its 95% confidence interval was 1.03（0. 74, 1.31 ）for comet tail length in radiation group, and was 0. 10 （0. 04, 0. 16） for comet tail moment compared with control group. Relative risk and its 95% confidence interval for chromosome aberration was 1.21 （0. 68, 2. 13 ）for lower than 2000 MHz RF-radiation exposure group, and 1.76（ 1.05, 2.97 ） for more than 2000 MHz RF-radiation exposure group. The combined relative risk and its 95% confidence interval for micronuclei formation was 1.39（1.18-1.64）. The combined WMD and its 95% confidence interval for sister chromatid exchanges in radiation group was 0. 40 （ - 0. 33,1.14 ） compared with control group. Conclusions On certain RF radiation exposure conditions, it can increase in the DNA damages and micronuclei formation.There might be an increase of chromosomal aberration occurrence for RF-radiation exposure above 2000 MHz, while no significant differences for those lower than 2000 MHz RF-radiation exposure. For the incidence of sister chromatid exchanges in mammalian somatic cells, RF-radiation exposure had no significant influence.