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诱导多功能干细胞-帕金森病治疗的未来 被引量：3

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摘要 诱导多功能干细胞（induced pluripotent stem cells,iPSCs）是指通过诱导已分化的成熟体细胞异位表达某个或某些基因从而重整编得到的多功能干细胞,它具有与胚胎干细胞（embryonic stem cells,ESCs）极其相似的高度增殖和多向分化潜能,可分化成为多巴胺能神经元,从而改善帕金森病患者黑质纹状体多巴胺能神经功能.同时,iPSCs具有无道德伦理障碍、无免疫排斥、取材简单、无创等优点,
作者 翁南川 张骏 詹仁雅
机构地区 浙江大学医学院附属第一医院神经外科 浙江省人民医院骨科
出处 《中华神经外科杂志》 CSCD 北大核心 2010年第12期1144-1146,共3页 Chinese Journal of Neurosurgery
关键词 多功能干细胞 帕金森病 多巴胺能神经元 多向分化潜能 cells 治疗 胚胎干细胞 黑质纹状体
分类号 R686 [医药卫生—骨科学]
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参考文献40

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二级参考文献12

共引文献75

同被引文献68

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引证文献3

中华神经外科杂志
2010年 第12期

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