摘要
目的探讨手足口病重症病例的早期临床特征及其有效治疗方法。方法总结分析120例手足口病重症病例的早期临床特征，包括年龄、临床症状体征、血液化验指标、治疗措施及预后。结果120例重症病例发病年龄主要集中在1～3岁，持续高热（55％）、血压升高（40％）、皮疹稀少（73．3％）是重要的早期临床特征；精神萎靡、嗜睡或哭闹（70．8％）、呕吐（30．8％）是手足口病重症病例早期即有的神经系统受累表现；肢体抖动或肌阵挛（80％）是重症病例中枢神经系统受累的特有表现；血白细胞升高（75．8％）和血糖升高（32．5％）是早期诊断手足口病重症病例的重要检测指标。采用20％甘露醇、丙种球蛋白、激素为主的早期治疗，患儿无1例死亡。结论手足口病重症病例早期以神经系统受累为主要临床特征，应及早给予甘露醇等药物治疗，预后良好。
Objective To discuss the early clinical features and effective treatment of severe hand-foot-mouth disease（ HFMD ）. Methods Early clinical features of 120 severe HFMD cases were retrospectively analyzed, including age, clinical symptoms and signs ,blood tests, treatment and prognosis. Results 88.3% of 120 severe cases were 1 -3 yeas old ;Sustained high fever155% ） , hypertension 140% ） , fewer rash（73.3% ） were important early clinical features. Sonmolence or restlessness（70.8% ） ,vomiting（ 30.8% ） were early signs of CNS involvement ;Trembling（ 80% ） was characteristic of CNS involvement in severe cases. High white cell count （75.8%） and high blood sugar （ 32.5% ） were important sign for early diagnosis of severe HFMD. There was no difference in the above characteristics between sever HFMD cases and ordinary cases （ P 〈 0.01 or P 〈 0.05 ）. No case died with early treatment including mannitol, gamma globulin, glucocorticosteroids, and no side effect was found. Conclusion Early treatment including mannitol was effective for severe HFMD cases with CNS involvement and the prognosis was good.
出处
《潍坊医学院学报》
2010年第5期363-365,共3页
Acta Academiae Medicinae Weifang
关键词
手足口病
重症病例
诊断
治疗
Hand-foot-mouth disease
Sever cases
Diagnosis
Treatment
