补肾祛湿中药联合多沙唑嗪治疗慢性附睾炎的临床研究

Kidney-tonifying and dampness-expelling Chinese herbal medicine combined with doxazosin for the treatment of chronic epididymitis

目的:了解补肾祛湿中药联合多沙唑嗪治疗慢性附睾炎的临床疗效。方法:64例慢性附睾炎患者随机均分为2组,每组32例。对照组仅服用多沙唑嗪,治疗组采用补肾祛湿中药联合多沙唑嗪治疗,每组患者接受药物治疗4周。使用慢性附睾炎症状指数评分表(CESI)、焦虑自评量表(SDS)、抑郁自评量表(SAS)等对治疗前后临床症状进行评估,并评价其疗效。结果:两组经治疗后,在CESI总均分、疼痛评分以及生活质量评分上皆有显著性改善(P<0.05);治疗组与对照组相比疗效更佳,差异有显著性(P<0.05)。治疗后两组患者在SAS及SDS评分上皆有显著性降低(P<0.05),但两组间比较无显著性差异(P>0.05)。结论:单独使用多沙唑嗪及补肾祛湿中药联合多沙唑嗪对慢性附睾炎皆有明显的临床疗效,但联合用药是一种更佳的治疗方法。

Objective：To study the clinical effects of kidney-tonifying and dampness-expelling Chinese herbal medicine combined with doxazosin in the treatment of chronic epididymitis.Methods：A total of 64 patients with chronic epididymitis were equally randomized into a treatment and a control group,the former treated with kidney-tonifying and dampness-expelling Chinese herbal decoction combined with doxazosin,and the latter given doxazosin only,both for 4 weeks.The clinical symptoms were measured by Chronic Epididymitis Symptom Index（CESI）,Self-Rating Anxiety Scale（SAS） and Self-Rating Depression Scale（SDS） before and after the treatment,and the therapeutic effects were evaluated. Results：After 4 weeks of medication,the total mean scores on CESI,pain,and quality of life（QOL） were significantly decreased in both the treatment and the control groups（P 0.05）,even more significantly in the former than in the latter（P 0.05）,and so were the scores on SAS and SDS（P 0.05）,but with no significant differences between the two groups（P 0.05）.Conclusion：Either doxazosin alone or kidney-tonifying and dampness-expelling Chinese herbal decoction combined with doxazosin is obviously effective on chronic epididymitis,but the combined medication produces an even better efficacy.