冠心病心绞痛患者血浆白细胞介素-6和超敏C-反应蛋白变化及其临床意义

Changes and clinical relevance of plasma interleukin-6 and high sensitive C-reactive protein in patients with coronary heart disease and angina

目的 探讨白细胞介素-6（IL-6）及超敏C-反应蛋白（hsCRp）在冠心病心绞痛发病机制中的作用.方法 选择冠状动脉造影确诊的心绞痛患者150例,分为不稳定型心绞痛（UAP）组78例,稳定型心绞痛（SAP）组72例,50例冠状动脉造影正常者作为对照组.采用酶联免疫吸附（ELISA）法检测血浆IL-6、免疫浊度法检测hsCRp水平.结果 UAP组血浆IL-6、hsCRP含量为（36.98±9.35）pg/L、（2.25±0.73）μg/L,显著高于SAP组的（23.19±7.35）pg/L和（1.88±0.68）μg/L（P均＜0.01）,2组IL-6、hsCRP均明显高于对照组（16.93±6.15）pg/L、（1.28±0.40）μg/L（P均＜0.01）.相关分析表明IL-6与hsCRP正相关,相关系数r=0.875（P＜0.05）.结论 炎症反应可能参与冠心病的发病过程,血浆IL-6与hsCRP对预测冠心病心绞痛的存在和发展有重要的临床意义.

Objective To explore the roles of interleukin-6 （IL-6） and high sensitive C-reactive protein （hsCRP） in coronary heart disease （CHD）. Methods One hundred and fifty patients diagnosed as angina pectoris by coronary angiography were enrolled and randomly divided into unstable angina pectoris group （ UAP group n =78） and stable angina group （SAP group n =72）. At the same time,50 cases with normal coronary angiography were selected as control. The plasma level of IL-6 was measured by ELISA, and hsCRP was measured by immunonephelometry. Results The mean plasma levels of IL-6 and hsCRP were significantly higher in UAP group compared with SAP group （ IL-6 （ 36. 98 ± 9. 35 ） pg/L vs. （ 23.19 ± 7. 35 ） pg/L; hsCRP （ 2. 25 ± 0. 73 ） μg/Lvs 1.88 ± 0. 68 ） μg/L; P 〈 0. 01 respectively）, both were significantly higher than those of control group （ IL-6 （16. 93 ± 6. 15 ）pg/L and hsCRP （1.28 ± 0.40）μg/L,P 〈0.01 respectively）. We also found significantly positive relationship between IL-6 and hsCRP plasma level （ r = 0. 875, P 〈 0. 05 ）. Conclusions Inflammatory response might play an important role in CHD. IL-6 and hsCRP were of high value in prediction of angina pectoris and development of CHD.