血清胱抑素C对高血压早期肾功能减退的临床价值

Clinical value of serum Cys-C in patients with renal insufficiency at the early stage of hypertension

目的探讨血清胱抑素C(Cys-C)水平对高血压早期肾功能减退的临床价值。方法根据血压情况,将61例研究对象分为3组:对照组、血压控制组和血压升高组,测定血清Cys-C、尿素氮(Bun)和肌酐(Cr)并进行对比分析。结果 3组间Cys-C测定值及Cys-C阳性率有统计学差异(P<0.01),而收缩压(SBP)、舒张压(DBP)、Bun及Cr值无显著性差异。结论 Cys-C是高血压早期肾功能减退的重要诊断指标之一,较Bun和Cr更敏感,有助于早期预测肾功能减退。

Objective To analyze the clinical value of serum Cys-C in patients with renal insufficiency at the early stage of hypertension.Methods According to blood pressure,61 patients were divided into three groups：control group,blood pressure baseline group and blood pressure uncontrolled group.Serum Cys-C,blood urea nitrogen（Bun）and creatinine（Cr）were determined and the data were compared and analyzed.Results The levels and positive rate of serum Cys-C were significantly different among three groups（P0.01）,but there were no significant differences in the levels of Bun and Cr among three groups.Conclusions Serum Cys-C plays an important role in patients with renal insufficiency at the early stage of hypertension.It is more sensitive than Bun and Cr.It contributes to predicting the renal insufficiency at the early stage.