1-(3,4,5三-甲氧基苯甲酰基)-苯并三唑的合成研究

Study on Synthesis of 1-(3,4,5-Trimethoxy-benzoyl)-benzotriazole

以3,4,5-三甲氧基苯甲酸为原料,酰氯化后与苯并三氮唑反应合成了1-(3,4,5-三甲氧基苯甲酰基)-苯并三唑,对其合成工艺进行了优化选择,得到了较佳的合成工艺。结果表明:以二氯甲烷为溶剂,三乙胺为催化剂,苯并三唑、3,4,5-三甲氧基苯甲酰氯和三乙胺的物质的量之比为1∶1∶1.2,0℃加料,在20℃下反应3 h,得率可达99%以上。

1-（3,4,5-Trimethoxy-benzoyl）-benzotriazole was synthesized from chlorinated 3,4,5-trimethoxy benzoic acid and benzotriazole.The synthesis process was optimized.The results showed that using dichloromethane as solvent,triethylamine as catalyst,molar ratio of benzotriazole,3,4,5-trimethoxybenzoyl chloride and triethylamine 1∶1∶1.2,added at 0 ℃,reaction 3 h under 20 ℃,the yield can reach 99 %.