四妙勇安汤加味治疗2型糖尿病大血管病变31例临床观察

Observation of Simiaoyongan decoction on the treatment of greater vascular disease in type Ⅱ diabetes cases

目的观察四妙勇安汤加味对2型糖尿病大血管病变的临床疗效。方法将62例2型糖尿病大血管病变患者随机分为2组,均积极控制血糖,治疗组31例予四妙勇安汤加味治疗,对照组31例予西洛他唑片治疗,2组均治疗1个月后观察疗效,分别做多普勒血流动力学、踝肱指数、外周血内皮素-1(ET-1)、血清一氧化氮(NO)水平检测。结果 2组愈显率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。2组治疗后踝肱指数均较本组治疗前升高(P<0.05)。2组治疗后ET-1均较本组治疗前降低(P<0.05)。2组治疗后NO均较本组治疗前升高(P<0.05)。结论四妙勇安汤加味可以改善2型糖尿病大血管病变患者的临床疗效,作用与西洛他唑片相当。

Objective To observe the effect of Simiaoyongan decoction on the treatment of greater vascular disease in type Ⅱ diabetes cases.Methods 62 patients with greater vascular disease in type Ⅱ diabetes were randomly divided into two groups.On the basis of controlling blood sugar,31 cases in treatment group were treated by Simiaoyongan decoction,31 cases in control group were treated by Cilostazol tablets.The course was a month in two groups.Microcirculation perfusion in local tissue,Ankle-brachial index,ET-1 in peripheral blood and level of NO in serum were detected before and after treatment.Results There was significant difference between two groups on cure and excellent rate（P〈0.05）.Ankle-brachial index after treatment was increased in comparison with that before treatment in two groups（P〈0.05）.ET-1 was decreased after treatment,and the level of NO in serum was increased in two groups（P〈0.05）.Conclusion Simiaoyongan decoction can improve vasomotoricity of patients with greater vascular disease in type Ⅱ diabetes,the effect was same to Cilostazol tablets.