长治市不同年龄组结核分枝杆菌原发耐药情况分析

Study on primary drug resistance of Mycobacterium tuberculosis in different age patients in Changzhi

目的分析长治市不同年龄组结核患者原发结核分枝杆菌的耐药情况,为制定控制结核病政策提供科学依据。方法将739例原发肺结核患者分为青年组、中年组和老年组,采用绝对浓度法的间接法进行抗结核药物的耐药性测定。结果青年组、中年组和老年组原发耐药率分别为31.3%,34.9%和24.5%,三组间差异无统计学意义(P>0.05)。原发耐药频率各年龄组从高到底依次为链霉素(SM)、异烟肼(INH)、利福平(RFP)、乙胺丁醇(EMR),其中青年组耐SM率最高为24.0%。原发耐多药率以中年组最高(5.5%),中年组和老年组差异有统计学意义(P<0.05)。结论长治市不同年龄组原发耐药率有一定差异,建议对高耐药年龄组的原发结核病患者给予重点关注。

Objective To investigate the primary drug resistance of Mycobacterium tuberculosis in different age patients in Changzhi,and to provide an evidence for the further development of TB control policy. Methods A total of 739 patients with primary pulmonary tuberculosis were divided into young group,middle age group and old group.The resistance of M.tuberculosis to streptomycin（SM） ,isoniazid（INH） ,rifampicin（RFP） and ethambutol（EMR） was tested by the absolute concentration method. Results The primary drug resistance rates were 31.3%,34.9% and 24.5% respectively in young group,middle age group and old group.There was no significant difference among 3 groups（P0.05） .The frequency of primary drug resistance from high to low in order was SM,INH,RFP and EMR in 3 groups.The primary drug resistance rate to SM in young group was the highest（24.0%） among three groups.The rate of primary multi-drug resistance in middle age group was the highest（5.5%） ,and there was significant difference between middle age group and old group（P0.05） . Conclusion Primary drug resistance varies in different age patients in Changzhi.The great attention should be paid to the age group of high drug resistance.