92株肠球菌的临床感染及耐药性分析

Analysis on Clinical Infection and Drug Resistance of 92 Enterococcus Strains

目的:了解肠球菌的临床感染特点和耐药性,为指导临床用药,控制感染提供依据.方法:回顾性分析2007年7月至2010年7月间从江汉大学附属医院临床标本中分离出的92株肠球菌的分布情况及药物敏感试验结果.结果:分离的92株肠球菌中粪肠球菌占73.9%,屎肠球菌13.1%,其他种类肠球菌13.0%.主要来源于尿液标本,占33.7%,且主要分布于干部病房和重症监护病房等科室.药敏结果显示耐药率最高的是环丙沙星38.0%和红霉素37.0%;青霉素G、氨苄西林和左旋氧氟沙星也呈中度耐药;替考拉宁和呋喃妥因的耐药率较低,为6.5%;未发现耐万古霉素和耐利奈唑胺的肠球菌.结论:该院肠球菌以粪肠球菌感染为主,主要引起泌尿道感染,对临床常用抗菌药物有不同程度的耐药,医务人员应根据药敏试验结果合理使用抗生素并加强对细菌耐药性的全面监测.

Objective：To investigate the infection and drug resistance of clinical Enterococcus strains isolated,and provide reference for the clinical therapy.Methods：Retrospectively survey and statistical analysis were carried out in the clinical distribution and antimicrobial susceptibility testing of Enterococcus strains isolated from July 2007 to July 2010.Results：There were 73.9% of Enterococcus faecalis,13.1% of Enterococcus faecium and 13.0% of other Enterococcus in 92 Enterococcus strains.The separated 92 Enterococcus strains were mainly from urine samples,ac-counting for 33.7%,and mainly distributed in cadre department and ICU department.The results of antimicrobial susceptibility testing showed that the highest resistance rate were ciprofloxacin 38.0% and erythromycin 37.0%;penicillin G,ampicillin and levofloxacin were also midrange re-sistance;the lower resistance rate were teicoplanin 6.5% and nitrofurantoin 6.5%.None of Enter-ococcus strains was resistant to vancomycin and linezolid.Conclusions：Enterococcus faecalis ma-inly caused urinary infection,and were resistant to some antibiotics.Medical staff should use anti-biotics reasonably and all-round supervision of drug resistance should be strengthened.