DAB诱发大鼠肝癌过程中IL-2、丙二醛动态变化

The change of IL-2、malonydialdehyde in rats induced liver carcinoma by DAB

目的 应用二甲基奶油黄（ＤＡＢ） 诱发大鼠肝癌，为了观察诱癌过程中大鼠ＩＬ－ ２ 、丙二醛（ ＭＤＡ） 动态变化及其相互关系。方法 在诱发大鼠肝癌的３ 个阶段分别取大鼠脾脏和外周血测定ＩＬ－ ２ 活性和丙二醛。结果 肝炎、肝硬化、肝癌期大鼠ＩＬ－ ２ 活性降低，ＭＤＡ 显著增高，Ｐ＜ ０ ．０５ 或０－０１ 。肝癌期大鼠ＩＬ－ ２ 活性与ＭＤＡ 呈负相关。结论 诱发大鼠肝癌过程中，ＩＬ－ ２ 活性逐步降低，ＭＤＡ 随着病情发展逐步增高，肝癌期ＩＬ－ ２ 活性下降与ＭＤＡ

Aim In order to observed IL-2 and Malonydialdehyde(MDA) in process of inducing liver carcinoma rats.Method We measured change of serum interleukin 2 of rat’s splenocytes and MDA in serum.Result The results showed that IL-2 in rats with hepatitis cirrosis and liver carcinoma stages decreased significantly,and MDA increased highly P<0.05 or 0.01.IL-2 is negative relative with MDA in liver carcinoma stage.Conclusion IL-2 decreased gradually,but MDA increased in process of inducing liver carcinoma rats by DAB,The IL-2 is related with MDA in liver carcinoma stage.