雄激素受体与肝细胞肝癌预后的关系

Androgen recepter as a prognostic factor of hepatocellular carcinoma

目的 探讨雄激素受体（ＡＲ） 与肝细胞肝癌（ ＨＣＣ） 的关系。方法 用葡聚糖包裹活性炭饱和吸附法检测４７例ＨＣＣ 癌组织和癌旁肝组织中ＡＲ 的含量。对４３ 例病人进行术后随访９ ～６０ 个月。结果 ３３ 例ＡＲ 阳性（３－０ ～１００ｆｍｏｌ／ｍｇ 蛋白） ，１４ 例ＡＲ 阴性。ＡＲ 阳性病人与ＡＲ 阴性病人的一、五年存活率没有统计学差别（ Ｐ＞ ０－０５） ，三年存活率ＡＲ 阳性者（３５－５ ％ ） 显著低于ＡＲ 阴性者（６６－７ ％ ）（ Ｐ＜ ０－０５） 。复发时间ＡＲ 阳性者（２１－４ ±１５－２ 月） 与ＡＲ 阴性者（３３－９±１３－９ 月） 有显著差异（ Ｐ＜ ０－０５） 。结论 雄激素能促进ＨＣＣ 的增长及对周围组织的侵袭，部分ＨＣＣ 具有雄激素依赖性，ＡＲ 可作为ＨＣＣ

Aim Studying androgen receptor(AR) in hepatocellular carcinoma (HCC)as a prognostic factor after hepatic resection.Method ARs in the cytosol of HCC were assayed by dextran-coated charcoal method in 47 patients in whom radical hepatic resection was performed.43 patients were followed up for 9-60 months.Results 33 patients had detectable amounts of ARs(ranging from 3.0 to 100fmol/mg protein).The receptor was not found in 14 cases.The 1-year and 5-year survival rate in the AR positive and AR negative groups were not statistically significant ( P >0 05) The 3-year survival rate was significantly better( P <0 05) in the AR negative group(66.7%) than that of AR positive group(35.5%).There were significantly difference in the recurrence time between patients with AR negative HCCs(33 9±13 9months)and those with AR positive tumors(21.4±15.2months) Conclusions Testosterone enhances the growth and invasion of human HCC,which is mediated by AR in the tumor.AR acts as a prognostic factor after hepatic resection.