nm23低表达及c—erb—B2过度表达与乳癌淋巴结转移的关系

Relationship between nm23 low expression and c erb B 2 over expression in breast cancer with lymphatic metastasis

目的 探讨ｎｍ２３及ｃ－ｅｒｂ－Ｂ２表达与乳癌生物学行为及淋巴结转移的关系。方法 应用免疫组化ＡＢＣ法对５８例乳癌中ｎｍ２３及ｃ－ｅｒｂ－Ｂ２表达进行测定。结果 ｎｍ２３低表达或ｃ－ｅｒｂ－Ｂ２过表达者淋巴结转移率明显高于正常表达率；在Ⅲ期乳癌中，ｃ－ｅｒｂ－Ｂ２过表达显著高于Ⅰ期在ｎｍ２３低表达组中，ｃ－ｅｒｂ－Ｂ２表达率明显高于对照组。

Objective To determine the relationship between nm23 and c erb B 2 experssion in breast cancer with lymphatic metastasis. Methods Determination was taken for nm23 and c erb B 2 expression levels in 58 patients with breast cancer by immunohistochemistry ABC assay. Results Lymphatic metastasis rate significantly increased in the patients with either nm23 low expression of c erb B 2 over expression(P<0.01), and the latter was elevated further in patients with stage Ⅲ breast cancer than those with stage Ⅰ breast cancer(P<0.05); c erb B 2 over expression rate was significantly higher in nm23 low expression group than that in the normal control group(P<0.01). Moreover, lymphatic metastasis rate was up to 88.9% in patients with both nm23 low expression and c erb B 2 over expression. Conclusions Detection of nm23 and c erb B 2 expression levels plays an important role in predictions of the occurrence of lymphatic metastasis and the prognosis in breast cancer, particularly for those represent both nm23 low expression and c erb B 2 over expression.